Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection

Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine1

Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action. HupA has been found to improve cogni...

Brief review: rivastigmine, a second cholinesterase inhibitor.

Cholinesterase-inhibitor Associated Mania: A Case Report and Literature Review.

Neuropsychiatric symptoms (NPS) are common in the middle to late stages of Alzheimer’s dementia (AD), but can also present in the Mild Cognitive Impairment (MCI) phase. Since the pathophysiology of AD involves deficits in central cholinergic neurotransmission, cholinesterase inhibitors (CHEIs) are effective in treating its cognitive symptoms. Interestingly, case studies have reported the onset ...

Prognostic Factors in Cholinesterase Inhibitor Poisoning

BACKGROUND Organophosphates and carbamates are insecticides that are associated with high human mortality. The purpose of this study is to investigate the prognostic factors affecting survival in patients with cholinesterase inhibitor (CI) poisoning. MATERIAL AND METHODS This study included 92 patients with CI poisoning in the period from January 2005 to August 2013. We divided these patients...

Synaptic NMDA receptor activity boosts intrinsic antioxidant defences

Intrinsic antioxidant defences are important for neuronal longevity. We show that synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosts antioxidant defences through changes to the thioredoxin-peroxiredoxin system. Synaptic activity enhances thioredoxin activity, facilitates the reduction of overoxidized peroxiredoxins, and promotes resistance to oxidative stress. Resistance is m...